synthesis and docking studies of new 4-oxo-1,3-thiazolidine derivatives as potential anticonvulsant agents
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چکیده
منابع مشابه
Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents
Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...
متن کاملDesign and Synthesis of 4-flurophthalimides as potential anticonvulsant agents
Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...
متن کاملdesign, synthesis and molecular modeling studies of new 2,3-diaryl thiazolidine-4-ones as potential microtubule-binding agents
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Synthesis and QSAR studies of 4-oxo-thiazolidines and 2-oxo-azetidines as potential antibacterial agents
Several 2-(4-chlorophenyl)-N-(4-oxo-2-aryl(l,3,thiazolidin-3-yl))acetamides 2, N-[3-chloro-4-(2-aryl)-2-oxo-azetidinyl]-2-(4-chlorophenyl)acetamides 3, N-(4-oxo-2-aryl(1,3,-thiadiazolidin-3-yl){4-[5-oxo-2-phenyl-4-(phenylmethylene) (2imidazolinyl)phenyl}carboxamides 7 and N-(3-chloro-2-oxo-4-arylazetidinyl){4-[5-oxo-2-phenyl-4-(phenylmethylene)(2imidazolinyl)] phenyl}carboxamides 8 have been sy...
متن کاملMolecular docking studies on xanthohumol derivatives as novel anticancer agents
A set of Xanthohumol derivatives were selected and molecular docking studies of these compounds on thioredoxin reductase were conducted. Based on new structural patterns using in silico-screening study, new potent lead compounds were designed. The results due to validated docking protocols lead to find that Thr58, Gly57, Gly21, Asp334, Glu163, Ala130, IIe332, Val44 and Gly132 are the main a...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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